Rabbit Epididymal Secretory Proteins. II. Immunolocalization and Sperm Association of REP381
نویسندگان
چکیده
منابع مشابه
Systematic mapping and functional analysis of a family of human epididymal secretory sperm-located proteins.
The mammalian spermatozoon has many cellular compartments, such as head and tail, permitting it to interact with the female reproductive tract and fertilize the egg. It acquires this fertilizing potential during transit through the epididymis, which secretes proteins that coat different sperm domains. Optimal levels of these proteins provide the spermatozoon with its ability to move to, bind to...
متن کاملParticipation of epididymal cysteine-rich secretory proteins in sperm-egg fusion and their potential use for male fertility regulation.
Rat protein DE is an androgen-dependent cysteine-rich secretory protein (CRISP) synthesized by proximal epididymal regions. DE, also known as CRISP-1, is localized on the equatorial segment of acrosome-reacted spermatozoa and participates in gamete fusion through binding to egg complementary sites. Immunization of rats with DE inhibits fertility and sperm fusion ability, suggesting that DE repr...
متن کاملA ram epididymal secretory protein shares common antigenic determinants with rat epididymal proteins and human seminal plasma proteins.
Mammalian spermatozoa leave the testis as immature cells unable to fertilize until they have traversed the epididymis. Sperm maturation is an orchestrated series of sequential events occurring at different levels of the epididymis : sperm-zona pellucida binding ability in the proximal epididymis, progressive motility and the ability to penetrate and fertilize the oocyte in the middle epididymis...
متن کاملEffects of ethanol treatment on epididymal secretory products and sperm maturation in albino rats.
Alcoholics are often associated with fertility disturbances with low sperm count and impaired sperm motility. Spermatozoa attains forward motility and fertilizing capacity during their transit through the epididymis. Epididymal secretory products form a suitable microenvironment, which favors sperm maturation. To study the effects of ethanol on epididymal sperm maturation, ethanol (3 g/kg body ...
متن کاملCharacterization of epididymal proteins Electrophoretic analysis of epididymal fluid proteins
© 1998 Journals of Reproduction and Fertility 1359-6004/98 $12.50 Before mammalian spermatozoa can interact with the egg in vivo, they are subjected to post-testicular modifications in the male as well as in the female genital tract. The evidence that this post-testicular maturation process requires exposure to a specific microenvironment within the epididymis has been reviewed elsewhere (Orgeb...
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ژورنال
عنوان ژورنال: Biology of Reproduction
سال: 2002
ISSN: 0006-3363,1529-7268
DOI: 10.1095/biolreprod67.1.140